Serum vitamin D levels in girls with central precocious puberty

Precocious puberty can cause several adverse effects on final growth and social behavior in girls. Recently studies showed that low serum vitamin D levels might be associated with precocious puberty. The aim of&nbsp; this research was to investigate the association between serum vitamin D levels and central precocious puberty in girls. Girls with central precocious puberty under the age of 8 were enrolled into the study. Subjects with brain tumor, inherent adrenal hyperplasia and thyroid dysfunction were excluded from the study. Age, weight, height, serum level of vitamin D concentration, LH, FSH, Estradiol, FT4, bone age, TSH and tanner stages were determined for all subjects. The healthy girls with no precocious puberty were considered as control group. Finally 58 girls (28 with central precocious puberty and 30 in control group) were enrolled to the study. The average of serum vitamin D levels were 12.9 &plusmn; 7.8 ng/mL and 15.2&plusmn;5.9 ng/mL in case and control groups respectively, (P = 0.02). The thirty seven percent of girls with puberty were in Tanner stage 2 and 63% in stage 3. The serum vitamin D level had considerable relationship with chronological-bone age difference (P < 0.01). Vitamin D deficiency was more common in girls with central precocious puberty than those with normal sexual maturation.. Insufficiency and deficiency of vitamin D were more common in girls who were evaluated in this study in comparison of other studies.